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Pharmacological Review on Centella asiatica:A Potential Herbal Cure-all

Date : 2018-6-8 2:44:57 Views :


Description of the plant:


Centella asiatica (CA), a clonal, perennial herbaceous creeper belonging to the family Umbellifere (Apiceae) is found throughout India growing in moist places up to an altitude of 1800m. It is found in most tropical and subtropical countries growing in swampy areas, including parts of India, Pakistan, Sri Lanka, Madagascar, and South Africa and South pacific and Eastern Europe. About 20 species related to CA grow in most parts of the tropic or wet pantropical areas such as rice
paddies, and also in rocky, higher elevations. It is a tasteless, odourless plant that thrives in and around water. It has small fan-shaped green leaves with white or light purple-to-pink or white fl owers and it bears small oval fruit. The whole plant is used for medicinal purposes. It is widely used as a blood purifier as well as for treating high blood pressure, for memory enhancement and promoting longevity. In Ayurveda, CA is one of the main herbs for revitalizing the nerves and brain cells. Eastern healers relied on CA to treat emotional disorders, such as depression, that were thought to be rooted in physical problems. In the Western medicine, during the middle of the twentieth century, CA and its alcohol extracts reported to have shown positive results in the treatment of leprosy.

Active constituents:


The primary active constituents of CA are saponins (also called triterpenoids), which include asiaticosides, in which a trisaccharide moiety is linked to the aglycone asiatic acid, madecassoside and madasiatic acid. These triterpene saponins and their sapogenins are mainly responsible for the wound healing and vascular effects by inhibiting the production of collagen at the wound site. Other components isolated from CA, such as brahmoside and brahminoside, may be responsible for CNS and uterorelaxant actions, but are yet to be confirmed by clinical studies. Crude extract containing glycosides isothankuniside and thankuniside showed antifertility action in mice. Centelloside and its derivatives are found to be effective in the treatment of venous hypertension. In addition, the total extract contains plant sterols, flavonoids, and other components with no known pharmacological activity[16], namely, abundant tannins (20-25%), essential acid (0.1% with beta-chariophylen, trans-beta-pharnesen and germachrene D), phytosterols (campesterol, sitosterol, stigmasterol), mucilages, resins, free aminoacids (alanine, serine, aminobutyrate,aspartate, glutamate, lysine and treonine), fl avonoids (derivates of chercetin and kempferol), an alkaloid (hydrochotine), a bitter component (vallerine), fatty acids (linoleic acids, linolnelic, oleic, palmitic and stearic acids).

Centella asiatica is an important medicinal herb that is widely used in the orient and is becoming popular in the West. Triterpenoid, saponins, the primary constituents of Centella asiatica are manly believed to be responsible for its wide therapeutic actions. Apart from wound healing, the herb is recommended for the treatment of various skin conditions such as leprosy, lupus, varicose ulcers, eczema, psoriasis, diarrhoea, fever, amenorrhea, diseases of the female genitourinary tract and also for relieving anxiety and improving cognition.


Product Name

Centella asiatica Extract

Botanical Source

Centella asiatica (L.) Urban

Part Used

Whole herb

Specifications

Total triterpenoids 6%-45%, asiaticoside 10%, Madecassosides

Appearance

Light Yellow powder


Reference:  

Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all

KASHMIRA J. GOHIL*, JAGRUTI A. PATEL AND ANURADHA K. GAJJAR 1

Department of Pharmacology, Maliba Pharmacy College, Bardoli-394 350, Department of Pharmacology, Institute of Pharmacy, Nirma University (NU), Ahmedabad-382 481, India


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